Here is an article how to integrate Twilio to your Google AppEngine project https://developers.google.com/appengine/articles/twilio. Upd: seems this code doesn’t work anymore
I’ve recently tried to integrate the latest Twilio python library to my GAE application. Version 3.6.2 fails with NotSupportedOnThisPlatform – Google Cloud Platform doesn’t support certificates in httplib2. Use 3.5.2 version instead.